The results also showed that RTA1st and RTAall-293 cells showed a 1.8 and 2.4 fold increase in total colonies in comparison to BAC36 wt-293 (Fig. 4E, F), providing further evidence that mutation of the RBP-Jκ sites enhanced KSHV latent infection and so promoted cell growth and proliferation. This evidence concerns the gene RBPJ and disease arising from reactivation of latent virus.