This is the case of Noonan-like syndrome with loose anagen hair (NL/LAH), a rare condition with clinical features partially overlapping those occurring in NS [Mazzanti et al., 2003], and caused by the invariant c.4A>G missense change (p.Ser2Gly) in SHOC2 [Cordeddu et al., 2009], a scaffold protein with regulatory function that positively modulate RAS signaling [Matsunaga-Udagawa et al., 2010; Rodriguez-Viciana et al., 2006]. This evidence concerns the gene SHOC2 and Noonan syndrome.