CSF2 and autoimmune pulmonary alveolar proteinosis: More than 90% of patients are idiopathic PAP(iPAP), is specifically associated with the presence of granulocyte-macrophage colony stimulating factor(GM-CSF) autoantibodies that are thought to mediate pathogenesis by eliminating GM-CSF bioactivity, thereby this loss of functional GM-CSF results in a filling of the alveolar spaces of the lungs with the lipoproteinaceous material called pulmonary surfactant[2,3].