We set out to test whether DNA methylation is also responsible for the silencing of FLT4. We determined the methylation status of KDR and FLT4 in human umbilical vein endothelial cells (HUVECs), dermal microvascular endothelial cells (HDMECs) and in a large panel of leukemia and lymphoma cell lines. This evidence concerns the gene FLT4 and leukemia.