EGFR and cancer: In particular, considering that a physical and functional interaction between EGFR and ER leads to the activation of multiple intracellular cascades, including MAPK, phosphoinositide 3-kinase (PI3K) and other protein kinases [50-53], it would be interesting to ascertain whether MIBE could alter these transduction signals that have been involved in the proliferation of cancer cells [50,54-58].