Preeclampsia is one of the most important diseases during pregnancy, but its molecular mechanisms are not fully understood yet.24 Since the role of the placenta in the pathogenesis of preeclampsia is undisputed, and Akt/PBK action in insulin resistance is evident,25-28 we analyzed the expression of Akt/PKB at the baseline and with insulin stimulation, in placental tissue from preeclampsia and normal pregnancies. This evidence concerns the gene PBK and preeclampsia.