PTGS2 and breast carcinoma: Breast cancer is the most common cancer in women and is the second biggest cause of cancer-related mortality in the world.6 Epidemiological studies have suggested that regular use of non-steroidal anti-inflammatory drugs (NSAIDs) may have some protective effect against breast cancer.7 Significantly reduced risk of human breast cancer relating to intake of selective COX-2 inhibitors has been reported.8