Furthermore, this observation is underscored by a study based on 120 colorectal cancer samples: MCAK expression is significantly higher at both the mRNA and protein levels, compared to paired corresponding normal tissues, and this elevated expression level is markedly correlated with lymph node metastasis, venous invasion, peritoneal dissemination, Dukes' classification and poor survival rate [99]. This evidence concerns the gene KIF2C and metastatic malignant neoplasm in the lymph nodes.