We then correlated the molecular analysis with the pathological characterization, according to Lauren’s classification, and we found a significant association between the diffuse histotype and the methylation status in the Reg2 of DLL1 promoter (Figure 4A); it was hypermethylated in 11/24 (46%) of the diffuse type of GC samples versus 1/24 (4%) of the intestinal type (p<0.0009). The gene discussed is DLL1; the disease is gastric cancer.