ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Despite such advances in the field, mutations rendering CML and Ph+ ALL patients non-responsive to TKI's have been identified, including the threonine 315 to isoleucine (T315I) mutation and several others, which differentially prevent binding of different TKIs to the active site of the ABL kinase domain, thereby evading inhibition [23].