Previous studies have established that TORC1 and TORC2 play critical roles in growth and survival of BCR-ABL transformed cells, including myeloid (CML) and lymphoid (Ph+ ALL) cells [36-38, 46-49], underscoring the importance and relevance of the mTOR pathway in the pathogenesis and pathophysiology of Ph+ malignancies. The gene discussed is CRTC2; the disease is acute lymphoblastic leukemia.