BCR and acute lymphoblastic leukemia: In one of the initial studies in which the effects of modulation of AMPK in ALL cells were assessed, the AMP-analog AMPK-activator compound 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) was shown to exert antiproliferative effects on childhood ALL cells, including the SupB15 cell line which expresses the p185 BCR-ABL fusion protein [56].