Previous studies have established that TORC1 and TORC2 play critical roles in growth and survival of BCR-ABL transformed cells, including myeloid (CML) and lymphoid (Ph+ ALL) cells [36-38, 46-49], underscoring the importance and relevance of the mTOR pathway in the pathogenesis and pathophysiology of Ph+ malignancies. This evidence concerns the gene CRTC1 and chronic myelogenous leukemia, BCR-ABL1 positive.