JAK2 and chronic myelogenous leukemia, BCR-ABL1 positive: Interestingly, recent studies have demonstrated that JAK2 inhibitors (TG101209, WP1193) and a dual kinase inhibitor of JAK2 and ABL kinases (ON044580) induce apoptosis in IM-sensitive and IM-resistant CML cell lines [116, 117] and that treatment with TKIs in combination with TG101209 results in greater inhibition of CML stem and progenitor cells, compared to treatment with either TKIs or TG101209 alone or a combination of TKIs (Chen, DeGeer and Jiang, unpublished data).