Both AHI-1 and BCR-ABL transcript levels are significantly increased in the CML stem cell-enriched population (lin−CD34+CD38−) as compared to normal BM (Figure 5A) [17, 106, 107] and AHI-1 and BCR-ABL transcript levels are significantly higher in CML stem/progenitor cells from IM-nonresponders and blast crisis patients compared to the same cells isolated from IM-responders [19]. This evidence concerns the gene CD38 and chronic myelogenous leukemia, BCR-ABL1 positive.