GZMB and neoplasm: However unlike Tgfb1f/nCd4cre-TRAMP mice where tumor protection was associated with frank increases in the expression of the effector molecules IFN-γ and GzmB by T cells in the tumor-draining lymph nodes and prostates[18], tumor protective immunity in Tgfb1f/nCd4cre-PyMT mice was associated with moderately increased expression of these effector molecules in Tgfb1f/nCd4cre-PyMT mice compared to Tgfb1f/n-PyMT mice (data not shown).