In Tgfb1f/nCd4cre-TRAMP mice, we found that protective tumor immunity was associated with T cell differentiation into IFN-γ- and granzyme (Gzm)B-producing effectors in the tumor draining lymph nodes and prostate[18] in line with reports showing that TGF-β1 suppressess antitumor immunity by transcriptional repression of the CTL program including the expression of IFN-γ and GzmB[54]. This evidence concerns the gene IFNG and neoplasm.