DPP4 and Hypoglycemia: Compared with other antihyperglycemic agents, DPP-4 inhibitors are associated with lower risks of hypoglycemia and weight gain than the sulfonylureas (SUs), lower risk of edema and chronic heart failure than the thiazolidinedione (TZDs), lower risk of diarrhea or gastrointestinal intolerance than metformin, and associated with fewer gastrointestinal adverse events than GLP-1 agonists [14-19].