Meta-analysis including all rare coding variants affecting the CLU β-chain domain observed in the discovery and replication cohorts plus those reported in 3 additional cohorts [14,15], totaling 5772 patients and controls, lent further support to an increased occurrence of rare coding variants predicted to affect the CLU β-chain in AD patients compared to healthy individuals (ORMH 1.96 [95% CI 1.18-3.25]; p = 0.009). Here, CLU is linked to Alzheimer disease.