CLU and Alzheimer disease: The stage I resequencing of the coding exons and the regulatory regions of CLU in patients and control individuals of the Flanders-Belgian AD cohort (n = 1930) (Table 1), identified in total 19 rare to intermediate rare non-synonymous single nucleotide variations predicting an amino acid substitution in the CLU protein of which only 5 had been reported earlier [14,15] (Table 2).