Namdar et al. [80] reported that HDAC6 inhibition with tubacin or shRNA activated the intrinsic apoptosis pathway in cancer cells; this led to accumulation of γH2AX, and the expression of growth arrest and DNA damage 153 (GADD153/DDIT3), a transcription factor upregulated in response to cellular stress. The gene discussed is DDIT3; the disease is cancer.