Curcumin also inhibits DNA repair pathways in cancer cells, like the fanconi anemia/BRCA (FA/BRCA) pathway [226], or downregulates DNA repair proteins MGMT (O6-methylguanine-DNA methyltransferase), DNAPK, Ku70, Ku80, and ERCC-1 [227]. The gene discussed is MGMT; the disease is Friedreich ataxia.