IGF1R and amyotrophic lateral sclerosis: Wilczak et al. investigated the components of the IGF-1 system in spinal cord sections of patients with ALS.29 They reported that free IGF-1 concentrations were lower in ventral horn homogenates from ALS patients than in those from controls; in addition, IGF-1R immunoreactivity was enhanced in ALS spinal MNs.