The lack of information available on the expression levels of the IGF-1 system in skeletal muscle of ALS patients led us to investigate the expression of IGF-1; IGF-BP3, -BP4, -BP5; and IGF-1R β subunit (IGF-1Rβ) in skeletal muscle specimens and primary muscle cell cultures obtained from sALS patients. This evidence concerns the gene IGF1 and amyotrophic lateral sclerosis.