DAPK1 and endometrium adenocarcinoma: In the human endometrial adenocarcinoma cell line HHUA, in which DAPK protein is highly expressed (25), targeted knockdown of DAPK protein expression with DAPK siRNAs enhanced 5-fluorouracil-sensitivity but not etoposide-sensitivity, suggesting that DAPK protein expression levels can regulate cellular sensitivity to some anticancer drugs (30).