DAPK1 and cervical squamous cell carcinoma: In the human cervical squamous cell carcinoma cell line ME180, which exhibits hypermethylation of normally unmethylated CpG islands in the promoter region of the DAPK gene (25), DAPK protein expression is constitutively suppressed but can be strongly induced by treatment with the demethylating agent 5-aza-2′-deoxycytidine (5-aza-CdR) (29).