On the other hand, inhibition of DAPK expression in HeLa cells, 3T3 fibroblasts, primary human vascular smooth muscle cells and various human uterine cancer cells using antisense DAPK or small-interfering RNAs (siRNAs) for DAPK was found to increase apoptosis (18,24,27,28). This evidence concerns the gene DAPK1 and uterine cancer.