PLK1 and neoplasm: Importantly, siRNA-mediated downgulation of PLK1 could recapitulate the tumor suppressor function of miR-100, and overexpression of PLK1 could partly rescue the reduced cellular proliferation observed upon miR-100 upregulation in SKOV-3 cells, demonstrating that PLK1 is an important functional target of miR-100 in this model.