Briefly, we found that mmu-miR-688 and mmu-miR-30c-1* targeting Tcf712 and Cdk4 are involved in colorectal and pancreatic cancer, respectively, while the same miRNAs targeting Bad, Mapk10, Mapk3 and Tgfbr1 are involved both in pancreatic as well as colorectal cancer. This evidence concerns the gene TGFBR1 and familial pancreatic carcinoma.