The PCDH10 CpG island (CGI) was methylated in KM3 and RPMI-8226 cells (Fig. 1B), while no methylation was detected in normal adult BM (Fig. 3B), samples showing that silencing of PCDH10 expression in MM was correlated with its methylation status. This evidence concerns the gene PCDH10 and Miyoshi myopathy.