INS and diabetes mellitus: The intra-abdominal obesity and recently discovered endogenous gland activity of adipose tissue producing various hormones and cytokines, such as angiotensinogen, insulin, resistin, lipoprotein lipase, leptin, lactate, plasminogen activator inhibitor, adipsin, and interleukin, seem to play a central role in the development of disadvantageous cardiometabolic profile and may represent the causal link between arterial hypertension, atherogenic dyslipidemia, diabetes, thrombosis, and inflammation [15].