Because our group previously demonstrated the expression of an anomalous tertiary structure of p53 protein in different peripheral cells derived from sporadic AD patients [17], [18] and many indications suggested p53 as a redox sensitive protein [19], [20], we also investigated whether a correlation between the expression of this conformationally altered p53 (unfolded p53) and oxidative profile in AD B lymphocytes exists. This evidence concerns the gene TP53 and Alzheimer disease.