Signal transducer and activator of transcription 1 (STAT1), the putative downstream effector of interferon (IFN), and interferon-related genes have been identified as key regulators of radiation resistance in preclinical models of head and neck squamous cell cancer [4], [5] and have been identified as radiation inducible in a wide variety of cancer cell lines, including glioma [5], [6]. This evidence concerns the gene STAT1 and cancer.