CXCR4 and cancer: Immunoblot and immunohistochemistry with the anti-phospho-PKCζ or anti-phospho-CXCR4 antibody further confirmed that PKCζ-shRNA reduced the expression of phosphorylated PKCζ and HGF-induced phosphorylated CXCR4 in cancer cells of the MDA-MB-436 xenografts (Figures 6E–6G, Figures S6,S7).