SRPX2 and neoplasm: The result indicates that SRPX2 is overexpressed in CRC during carcinogenesis and tumor progression, unlike SRPX. Real-time RT-PCR for the 30 CRC and 10 paired non-cancerous colonic mucosa samples confirmed that SRPX2 mRNA was markedly overexpressed in the CRC samples but was only expressed at a very low level in non-cancerous colonic mucosa (Figure 1B).