Next, to unveil the radiosensitizing efficacy of EKB-569, HNSCC cells mock-irradiated, exposed to IR or treated with EKB-569 (0.5, 1.0, 2.0 or 5.0 μg) and then exposed to IR were analyzed for alterations in NFκB activity. The gene discussed is NFKB1; the disease is head and neck squamous cell carcinoma.