Recently, Heist et al. demonstrated that the T allele of VDR FokI polymorphism and the G-T-C (Cdx2-FokI-BsmI) haplotype are associated with significantly worse survival in patients with advanced non-small-cell lung cancer; this was a report to show a relationship between VDR polymorphisms and prognosis of patients with cancer [19]. This evidence concerns the gene VDR and cancer.