OFCC1 and schizophrenia: In this study, we first investigated the relationship between MRDS1/OFCC1 and normal craniofacial and eye development, as well as schizophrenia, by generating and examining mice deficient in the gene corresponding to human MRDS1/OFCC1 and medaka opo. In addition, we tested the hypothesis of genetic association between the MRDS1 and schizophrenia using family-based association analysis, in a Japanese cohort.