In murine models, RF ablation induced strong upregulation of mRNA and/or protein levels of HSP-70, HSP-90, and glycoprotein 96 (gp96) as well as translocation of nuclear high-mobility group protein B1 (HMGB1) into the cytoplasm of tumor cells and into the intercellular space [55–57]. The gene discussed is HMGB1; the disease is neoplasm.