Since in adenomyosis IL-6 is over expressed [69], this could lead to increased oestrogen receptor expression and, indeed, the expression of the different isoforms of oestrogen receptor alpha (ER-α) and beta (ER-β) and progesterone receptor A (PR-A) and B (PR-B) are differentially modulated in uteri with adenomyosis compared with controls [71]. The gene discussed is ESR2; the disease is adenomyosis.