GDF5 and Weill-Marchesani syndrome: Another possibility is that mutations causing SSKS or WMS perturb growth factor signaling, since fibrillin-1 targets and sequesters the large latent Transforming Growth Factor β (TGFβ) complex [13], [14] as well as multiple Bone Morphogenetic Proteins (BMPs) and Growth and Differentiation Factor-5 (GDF-5) [15]–[17].