PLOD1 and viral infectious disease: While the induction of T1-IFNs in vivo following systemic (intravenous (i.v.)or intraperitoneal (i.p.)administration of viruses has been studied to a great extent [26]–[28] and their ability to induce an antiviral response is well known [1], we still lack an understanding of how T1-IFNs and ISGs are temporally induced and protect from disease during the course of the many viral infections that follow a stepwise mode of LH dissemination [16].