However, this immunosuppression is not absolute and IL-1β contributes to resistance to B. anthracis even in the absence of LT-responsive Nlrp1b; animals expressing LT-resistant alleles of Nlrp1b and lacking IL-1R or MyD88 (required for TLR and IL-1R signaling) show increased sensitivity to infection by B. anthracis[35]–[38]. This evidence concerns the gene IL1B and infection.