In support for a deleterious role of neutrophils in melioidosis we found that inhibition of their recruitment by administration of IL-1ra or the CXCR2 neutrophil chemokine receptor antagonist antileukinate protected Nlrc4-/- mice from infection with low doses of B. pseudomallei and decreased systemic spread of bacteria (figure 6). Here, NLRC4 is linked to infection.