Confirming the different susceptibilities of Il-18-/- and Il-1r1-/- mice to melioidosis, the bacterial burdens observed in the lungs, spleens, livers, and BALF of infected Il-18-/- mice were dramatically higher than that of WT mice even at early time points (24 hours post infection, figure 3B). The gene discussed is IL1R1; the disease is infection.