On this basis, we would expect cisplatin to show synergy with HSV in bladder TCC because cisplatin has been shown to upregulate GADD34 in malignant mesothelioma and head/neck squamous carcinoma cell lines (Adusumilli et al, 2006; Fishel et al, 2006). The gene discussed is PPP1R15A; the disease is malignant mesothelioma.