Innate tumour suppression in response to oncogenic stress includes the well-characterised ARF-mediated activation and stabilisation of p53 (Zindy et al, 2003; Christophorou et al, 2006; Efeyan et al, 2006) and the cellular DNA damage response (DDR) that is activated following oncogene-induced replicative stress (Halazonetis et al, 2008). Here, TP53 is linked to neoplasm.