We observed that the invasive ductal carcinoma (p = 0.046) and unspecified invasive breast carcinoma (p = 0.005) showed a significant under-expression of HADHA gene but lobular carcinoma (p = 0.781), invasive lobular carcinoma (p = 0.780) or invasive mixed carcinoma (p = 0.717) did not show a significant alteration of HADHA gene expression. The gene discussed is HADHA; the disease is invasive lobular breast carcinoma.