They also showed that a GSK-3beta inhibitor, SB216763, reduced myocardial infarct size in diabetic rats as well as in non-diabetic rats, and suggested that the mechanism of diabetes-induced attenuation could be due to impairment of protective upstream signaling pathways such as PI3K-Akt and ERK 1/2. This evidence concerns the gene GSK3B and myocardial infarction.