We observed that the addition of the neutralizing TGFβ antibody to the MMP-2 null osteoblast conditioned media had no impact on tumor survival (Fig. 7B–C), while the addition of recombinant MMP-2 to conditioned media from MMP-2 null primary osteoblasts rescued the tumor survival phenotype (Fig. 7C). Here, TGFB1 is linked to neoplasm.