Chronically HIV-1 infected individuals with controlled HIV infection (n = 25; median viral load 810 RNA copies/ml and median CD4 cell count 642 cells/mm3) and non-controlled viral replication (n = 25; viral load median viral load 200,000 RNA copies/ml and median CD4 cell counts 98 cells/mm3) were recruited from the HIV Unit in Hospital Germans Trias i Pujol, Badalona, Spain. This evidence concerns the gene CD4 and HIV infectious disease.