In a recent study, Hines et al. [3] reported that family history (FH) was significantly associated with an increased risk of both ER+ and ER− breast cancers among non-Hispanic White (NHW) women; however, among Hispanic women, having a family history was associated with an increased risk of ER− but not ER+e tumors, indicating a distinct pattern of breast cancer among Hispanics. The gene discussed is ESR1; the disease is breast cancer.