Table 3 presents the results for the genes in these pathways. The three NMNAT genes (NMNAT1, NMNAT2, and NMNAT3) that are shared by both of these two pathways harbor SNPs with significant genetic effect (Ptrend<0.05) and therefore likely to dominate the significant enrichment signals in these pathways. Other genes displaying significant bladder cancer risk are QPRT in the “NAD I” pathway, and ACP6, ITGB1BP3, ACPL2 in the “NAD II” pathway. The gene discussed is NMRK2; the disease is urinary bladder cancer.