Assessment of atherosclerotic lesions after feeding mice a HFD by oil red-O stained lipid accumulation showed that BaffR.ApoE DKO mice had a significant ∼44% reduction in aortic atherosclerosis compared to ApoE KO mice (p<0.01; Figure 2 A). This evidence concerns the gene TNFRSF13C and aortic atherosclerosis.