Exploration of these variants in European Caucasian populations represented by the DIAGRAM Consortium [3] and MAGIC [16] revealed only nominal evidence of association with T2DM (rs7107217 P = 0.086, located intergenically between BARX2 and NFRKB; Table S4) and did not provide further insight into the probable role of these variants in disease susceptibility through examination of quantitative measures of glucose homeostasis (Table S6), respectively. This evidence concerns the gene NFRKB and type 2 diabetes mellitus.