When circulating T-cell subsets in HIV+ patients were compared with healthy blood donors [15], a tendency to reduced median numbers of CD8+ cells (0.36×109/l; range, 0.057–1.67×109/l versus 0.405×109/l; range, 0.18–1.23×109/l) was observed while the CD4 counts were, as expected, significantly (p<0.0001) reduced (0.020×109/l; range, 0.0012–0.25×109/l versus 0.815×109/l; range, 0.5–1.58×109/l) – particularly in late stage (Group II, 0.019×109/l) and preterminal (Group III, 0.015×109/l) AIDS patients. This evidence concerns the gene CD8A and AIDS.