It also became apparent to us that in addition to their role in cardiovascular disease, the immunome signature of chagasic patients (ANXA2, ARHGDIA, FSCN1, GNB2L1, HSP90AB1, HSPA5, HSPA8, P4HB, PKM2, VIM, YWHAE, p-value: 1.37E-09) was also indicative of gastrointestinal disorder. The gene discussed is ARHGDIA; the disease is cardiovascular disorder.