It also became apparent to us that in addition to their role in cardiovascular disease, the immunome signature of chagasic patients (ANXA2, ARHGDIA, FSCN1, GNB2L1, HSP90AB1, HSPA5, HSPA8, P4HB, PKM2, VIM, YWHAE, p-value: 1.37E-09) was also indicative of gastrointestinal disorder. This evidence concerns the gene HSPA5 and digestive system disorder.