In addition, CXCR3B, the dominant CXCR3 splice variant in normal prostate epithelial cells (RWPE-1), was replaced in part by CXCR3A in invasive and metastatic prostate cancer cell lines (DU-145 and PC-3) and promoted cell motility and invasiveness in vitro. This evidence concerns the gene CXCR3 and metastatic prostate carcinoma.