Additionally, the result from in situ hybridization targeting CXCR3 in 5 normal prostate, 6 localized prostate cancer and 6 metastatic prostate cancer samples showed that CXCR3 mRNA expression significantly upregulated in localized and metastatic prostate cancer patients (Figure 2), which was consistent with CXCR3 protein expression profile in prostate cancer. This evidence concerns the gene CXCR3 and Familial prostate cancer.