For example, Chen and colleagues have shown that, during early infection with vesicular stomatitis virus, mice treated with the 5-LO antagonist Zileuton and 5-LO knock-out mice both presented an impaired infiltration process of neutrophils into the CNS, as well as fewer neurons expressing nitric oxide synthase-1, higher viral titres and increased disruption of the BBB [104]. Here, ALOX5 is linked to infection.