The relevance of abnormal Wnt-signalling activation in IPF is confirmed by the up-modulation of various Wnt-pathway molecular targets observed in IPF (MMP7, cyclin-D1 and others) [80], as well as by the demonstration that experimental fibrosis can be attenuated by the Wnt/β-catenin pathway blockade [83]. The gene discussed is MMP7; the disease is idiopathic pulmonary fibrosis.