TIMP1 and neoplasm: Moreover, as compared to normal endothelium, tumor endothelium showed gain of function of numerous proangiogenic molecules such as integrin β3, PlGF, VEGFR1, Nur77, Ang2, eNOS, TGFβ, MCP-1, TIMP-1, and t-PA, while loss of function was observed for vessel stability genes such as Ang1 and Tie2.