Similarly, the ratio between the pro-apoptotic gene Tsp-1 [25] and the antiapoptotic Bcl2 shifted from 1.9 in the tumor to 13.6 in the tumor vasculature, which may point to a relatively higher degree of Tsp1-induced proapoptotic signaling in the tumor vasculature compared to the non-vascular tumor compartment. This evidence concerns the gene THBS1 and neoplasm.